Hydrogen chloride-ethyl acetate → HCID 23155876, compound

HRID 1714808Notes

Reaction equation

HRID 1714808 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([OH:24])[CH:22]=3)[CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25].C(OCC)(=O)C>>[ClH:25].[OH:24][C:21]1[CH:22]=[C:23]2[C:18]([CH:17]=[CH:16][N:15]=[C:14]2[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23155947HCID 23155947, compound

Product 1

HCID 23155876HCID 23155876, compoundYield 78%

Procedure

A mixture of 70 mg of 1-(4-tert-butoxycarbonylpiperazin-1-yl)-7-hydroxyisoquinoline as synthesized in the above step and 3 ml of 4N hydrochloric acid-ethyl acetate solution was stirred for an hour at room temperature. So formed crystalline product was recovered by filtration and washed with ethyl acetate to provide 43 mg (yield: 78%) of 7-hydroxy-1-piperazin-1-ylisoquinoline hydrochloride.

Workup

  1. filtrationSo formed crystalline product was recovered by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-c99d4a7ab31344a4a1cad0e30ff000b8
Source dataset
uspto-grants-2010_09
Patent number
US07799775B2

Reaction notes

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