Hydrogen chloride-ethyl acetate → HCID 23155876, compound

Participants

Reaction Steps

A mixture of 70 mg of 1-(4-tert-butoxycarbonylpiperazin-1-yl)-7-hydroxyisoquinoline as synthesized in the above step and 3 ml of 4N hydrochloric acid-ethyl acetate solution was stirred for an hour at room temperature. So formed crystalline product was recovered by filtration and washed with ethyl acetate to provide 43 mg (yield: 78%) of 7-hydroxy-1-piperazin-1-ylisoquinoline hydrochloride.

Provenance & Evidence