Acetyl chloride → N-(6-benzenesulfonyl-naphthalen-1-ylmethyl)-acetamide

HRID 1715062Notes

Reaction equation

HRID 1715062 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[C:16]([CH2:20][NH2:21])=[CH:15][CH:14]=[CH:13]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:22](Cl)(=[O:24])[CH3:23]>N1C=CC=CC=1>[C:1]1([S:7]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[C:16]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])=[CH:15][CH:14]=[CH:13]3)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 59028770C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine

Product 1

HCID 59028777N-(6-benzenesulfonyl-naphthalen-1-ylmethyl)-acetamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine is dissolved in pyridine and acetyl chloride is added. The reaction mixture is stirred at room temperature and then quenched by addition of water. The mixture is extracted with EtOAc, and the organic layer is dried (MgSO4), filtered, and concentrated under reduced pressure to give N-(6-benzenesulfonyl-naphthalen-1-ylmethyl)-acetamide.

Workup

  1. customquenched by addition of water
  2. extractionThe mixture is extracted with EtOAc
  3. dry with materialthe organic layer is dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c3f39a7750534187aa98626e16d76b50
Source dataset
uspto-grants-2010_09
Patent number
US07799797B2

Reaction notes

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