Hydrochloric Acid → HCID 67442415, compound

HRID 1715086Notes

Reaction equation

HRID 1715086 reaction equation
Cl.[OH:2][C@@H:3]1[C@H:7]2[N:8](C(OC(C)(C)C)=O)[CH2:9][C@H:10]([S:11][CH3:12])[C@H:6]2[O:5][CH2:4]1>O1CCOCC1>[CH3:12][S:11][C@H:10]1[CH2:9][NH:8][C@@H:7]2[C@@H:3]([OH:2])[CH2:4][O:5][C@H:6]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67439721HCID 67439721, compound

Product 1

HCID 67442415HCID 67442415, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of HCl in 1,4-dioxane (4M, 5.5 mL) was added to thiomethylether (54) (152 mg, 0.55 mmol). The mixture stirred for 1 hour then the solvents removed in vacuo. The residue was azeotroped with CH3CN (5 mL) to obtain (3R,3aR,6S,6aS)-6-(methylthio)hexahydro-2H-furo[3,2-b]pyrrol-3-ol which was used without further purification.

Workup

  1. customthe solvents removed in vacuo
  2. customThe residue was azeotroped with CH3CN (5 mL)

Sources & evidence

ORD record
ord-1e8f0f7f834e4e06988dedbeeb095749
Source dataset
uspto-grants-2010_09
Patent number
US07799791B2

Reaction notes

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