Hydrochloric Acid → HCID 44140433, compound

HRID 1715114Notes

Reaction equation

HRID 1715114 reaction equation
[CH2:1]([O:4][C:5]([C:7]1[CH:29]=[CH:28][C:10]2[N:11]([CH:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[C:12]([CH3:14])=[N:13][C:9]=2[CH:8]=1)=[O:6])[CH:2]=[CH2:3].[ClH:30]>O1CCOCC1>[ClH:30].[ClH:30].[CH2:1]([O:4][C:5]([C:7]1[CH:29]=[CH:28][C:10]2[N:11]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([CH3:14])=[N:13][C:9]=2[CH:8]=1)=[O:6])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68506452HCID 68506452, compound

Product 1

HCID 44140433HCID 44140433, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 1-(1-tert-butoxycarbonyl-piperidin-4-yl)-2-methyl-1H-benzoimidazole-5-carboxylic acid allyl ester (1.60 g, 4.01 mmol) in dioxane (20 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 300.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-16cf40aeecbe4af5a5c3cf279b0de2fb
Source dataset
uspto-grants-2010_09
Patent number
US07799806B2

Reaction notes

Loading…