Hydrochloric Acid → HCID 68507565, compound

HRID 1715120Notes

Reaction equation

HRID 1715120 reaction equation
[CH2:1]([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]([CH:17]1[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]1)[CH2:12][C:11](=[O:30])[NH:10]2)=[O:6])[CH:2]=[CH2:3].[ClH:31]>O1CCOCC1>[ClH:31].[ClH:31].[CH2:1]([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)[CH2:12][C:11](=[O:30])[NH:10]2)=[O:6])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68508908HCID 68508908, compound

Product 1

HCID 68507565HCID 68507565, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 1-(1-tert-butoxycarbonyl-piperidin-4-yl)-3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid allyl ester (1.40 g, 3.37 mmol) in dioxane (20 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 316.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-0279f6b34e0243f49dd9b414d9a72f33
Source dataset
uspto-grants-2010_09
Patent number
US07799806B2

Reaction notes

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