2-Amino-4-methylthiazole → HCID 59383112, compound

HRID 1715174Notes

Reaction equation

HRID 1715174 reaction equation
[C:1](=[NH:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C:16]1[S:17][CH:18]=[C:19]([CH3:21])[N:20]=1>C1(C)C=CC=CC=1>[C:1](=[N:14][C:16]1[S:17][CH:18]=[C:19]([CH3:21])[N:20]=1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 136809Benzophenone imine

Product 1

HCID 59383112HCID 59383112, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Benzophenone imine (39.8 g, 0.22 mol) is added to a solution of 2-amino-4-methyl-1,3-thiazole (30 g, 260 ml) in toluene (450 ml) and heated at reflux under an inert atmosphere for 18 h. The mixture is cooled to room temperature and washed with citrate buffer (2×250 ml), water (2×250 ml), brine (2×250 ml), dried (MgSO4 and decolourising charcoal), filtered and evaporated to an orange solid.

Workup

  1. temperatureheated
  2. temperatureat reflux under an inert atmosphere for 18 h
  3. washwashed with citrate buffer (2×250 ml), water (2×250 ml), brine (2×250 ml)
  4. dry with materialdried (MgSO4 and decolourising charcoal)
  5. filtrationfiltered
  6. customevaporated to an orange solid

Sources & evidence

ORD record
ord-31fa733ff52b4affa8571751f47bc5bd
Source dataset
uspto-grants-2010_09
Patent number
US07799810B2

Reaction notes

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