Nitroethane → HCID 68506476, compound

HRID 1715177Notes

Reaction equation

HRID 1715177 reaction equation
[N:1]1([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.C([O-])(=O)C.[NH4+].[N+:19]([CH2:22][CH3:23])([O-:21])=[O:20]>>[N+:19]([CH:22]([CH3:23])[CH2:10][C:9]1[CH:12]=[CH:13][C:6]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)=[CH:7][CH:8]=1)([O-:21])=[O:20]

Participants

4

Reactant 3

HCID 6587NitroethaneHCID 517165Ammonium AcetateHCID 27764774-(1H-Pyrazol-1-yl)benzaldehyde

Product 1

HCID 68506476HCID 68506476, compound

Procedure

A mixture comprising 4-pyrazol-1-yl-benzaldehyde (7.0 g, 40.65 mmol), ammonium acetate (0.94 g, 12.19 mmol) and nitroethane (24 ml, 333.3 mmol) is stirred at reflux for 10 hours. The solvent is removed in vacuo and the resulting solid is dissolved in EtOAc and washed with water (3×50 ml). The organic portion is dried (MgSO4) and concentrated in vacuo to afford the title compound as an orange solid. [MH+ 230.1].

Workup

  1. temperatureat reflux for 10 hours
  2. customThe solvent is removed in vacuo
  3. dissolutionthe resulting solid is dissolved in EtOAc
  4. washwashed with water (3×50 ml)
  5. dry with materialThe organic portion is dried (MgSO4)
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a425e72ab2234b3a82a91c04689307af
Source dataset
uspto-grants-2010_09
Patent number
US07799810B2

Reaction notes

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