Hydrochloric Acid → HCID 59323907, compound

HRID 1715184Notes

Reaction equation

HRID 1715184 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:14][C:13]([NH:15]C(=O)C)=[N:12][C:11]=2[CH3:19])=[CH:6][C:5]=1[F:20])(=[O:3])[CH3:2].Cl>CCO>[NH2:15][C:13]1[S:14][C:10]([C:7]2[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH3:2])=[C:5]([F:20])[CH:6]=2)=[C:11]([CH3:19])[N:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59323903HCID 59323903, compound

Product 1

HCID 59323907HCID 59323907, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[5-(4-Acetyl-3-fluoro-phenyl)-4-methyl-thiazol-2-yl]-acetamide (0.46 g, 0.171 mmol) in EtOH (15 ml) is treated with 6M HCl (3.14 ml) and heated using microwave radiation at 100° C. After 90 minutes, the solvent is removed in vacuo and the resulting solid is dissolved in water (25 ml). The pH is adjusted to pH 7 by addition of 2M NaOH. The yellow solid which precipitates is filtered and dried under vacuum to afford the title compound. (MH+ 251.22).

Workup

  1. temperatureheated
  2. customat 100° C
  3. customthe solvent is removed in vacuo
  4. dissolutionthe resulting solid is dissolved in water (25 ml)
  5. additionThe pH is adjusted to pH 7 by addition of 2M NaOH
  6. customThe yellow solid which precipitates
  7. filtrationis filtered
  8. customdried under vacuum

Sources & evidence

ORD record
ord-d329d4d2137043fc9de54b5548fba10a
Source dataset
uspto-grants-2010_09
Patent number
US07799810B2

Reaction notes

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