Methanol → HCID 68506502, compound

HRID 1715186Notes

Reaction equation

HRID 1715186 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:18])[NH:11][C:12]1[CH:16]=[C:15]([CH3:17])[O:14][N:13]=1)(C)(C)C.[Si]([I:24])(C)(C)C.CO>CC#N>[IH:24].[NH2:7][CH2:8][CH2:9][C:10]([NH:11][C:12]1[CH:16]=[C:15]([CH3:17])[O:14][N:13]=1)=[O:18]

Participants

5

Reactant 3

HCID 887MethanolHCID 85247Trimethylsilyl iodideHCID 47120084HCID 47120084, compound

Product 1

HCID 68506502HCID 68506502, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a stirred solution of [2-(5-methyl-isoxazol-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (0.1 g, 0.37 mmol) in MeCN (3 ml) is added dropwise TMSI (0.11 ml, 0.74 mmol). After 30 minutes, MeOH (1 ml) is added to afford a yellow suspension which is collected by filtration and washed with EtOAc to afford the title compound. Further product is obtained by concentration of the filtrate.

Workup

  1. customto afford a yellow suspension which
  2. filtrationis collected by filtration
  3. washwashed with EtOAc

Sources & evidence

ORD record
ord-583b7b5ec62b44d183f2945035335ea4
Source dataset
uspto-grants-2010_09
Patent number
US07799810B2

Reaction notes

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