Hydrochloric Acid → HCID 68507720, compound

HRID 1715191Notes

Reaction equation

HRID 1715191 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:17])[NH:11][C:12]1[CH:16]=[CH:15][O:14][N:13]=1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[NH2:7][CH2:8][CH2:9][C:10]([NH:11][C:12]1[CH:16]=[CH:15][O:14][N:13]=1)=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68507383HCID 68507383, compound

Product 1

HCID 68507720HCID 68507720, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

[2-(Isoxazol-3-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (0.702 g, 2.76 mmol) in dioxane (5 ml) is treated with 4M HCl in dioxane (3.44 ml) and stirred at room temperature for 3 days. The solvent is removed in vacuo and co-evaporated with toluene to afford the title compound as a pale brown solid.

Workup

  1. customThe solvent is removed in vacuo and co-evaporated with toluene

Sources & evidence

ORD record
ord-e895b4f9f2e649c0be519a7826b2b917
Source dataset
uspto-grants-2010_09
Patent number
US07799810B2

Reaction notes

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