Isopropyl iodide → HCID 86621991, compound

HRID 1715255Notes

Reaction equation

HRID 1715255 reaction equation
[CH:1]1[N:2]=[CH:3][N:4]2[C:9]=1[CH2:8][CH2:7][NH:6][C:5]2=[O:10].[I:11][CH:12]([CH3:14])[CH3:13]>CN(C=O)C>[I-:11].[CH:12]([N+:2]1[CH:1]=[C:9]2[N:4]([C:5](=[O:10])[NH:6][CH2:7][CH2:8]2)[CH:3]=1)([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 6362Isopropyl iodideHCID 14875185H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one

Product 1

HCID 86621991HCID 86621991, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a suspension of 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one, obtained in step I as describe above (28.18 g; 205.5 mmol; 1 eq), in DMF (140.9 ml), is added 2-iodopropane (61.5 ml; 616.4 mmol; 3 eq). The reaction is stirred at RT, until a red suspension is obtained. The reaction mixture is concentrated and acetonitrile (200 ml) is added. The resulting precipitate is filtered, washed with acetonitrile (2×50 ml) and dried under vacuum, affording the title compound that is used in the next step without further purification (45.95 g, 73%).

Workup

  1. customobtained in step I
  2. customis obtained
  3. concentrationThe reaction mixture is concentrated
  4. additionacetonitrile (200 ml) is added
  5. filtrationThe resulting precipitate is filtered
  6. washwashed with acetonitrile (2×50 ml)
  7. customdried under vacuum

Sources & evidence

ORD record
ord-515bc18b86e54be095fc6773a21ae96f
Source dataset
uspto-grants-2010_09
Patent number
US07799814B2

Reaction notes

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