反应详情

To a suspension of 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one, obtained in step I as describe above (28.18 g; 205.5 mmol; 1 eq), in DMF (140.9 ml), is added 2-iodopropane (61.5 ml; 616.4 mmol; 3 eq). The reaction is stirred at RT, until a red suspension is obtained. The reaction mixture is concentrated and acetonitrile (200 ml) is added. The resulting precipitate is filtered, washed with acetonitrile (2×50 ml) and dried under vacuum, affording the title compound that is used in the next step without further purification (45.95 g, 73%).

1. customobtained in step I
2. customis obtained
3. concentrationThe reaction mixture is concentrated
4. additionacetonitrile (200 ml) is added
5. filtrationThe resulting precipitate is filtered
6. washwashed with acetonitrile (2×50 ml)
7. customdried under vacuum