HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 5-(2,2,2-Trifluoroacetyl)thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 5-trifluoroacetyl-2-thenoate | HCID 24726843 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 5-(2,2,2-Trifluoroacetyl)thiophene-2-carboxylic acid | HCID 24274701 | — |
Reaction Steps
Ethyl 5-(trifluoroacetyl)thiophene-2-carboxylate was hydrolysed with LiOH (2.1 eq.) in MeOH/H2O (1:1) at RT for 48 h. The mixture was concentrated under reduced pressure and extracted with EtOAc. The organic phase was washed with brine, dried (Na2SO4) and concentrated under reduced pressure to give the title compound as white solid. MS (ES) C7H3F3O3S requires: 224, found: 243 (M+H2O+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799825B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-1e63f3e69eab4a4a8d4bcded5c82f4a6 |
| Source note | uspto-grants-2010_09 |