反应详情

Ethyl 5-(trifluoroacetyl)thiophene-2-carboxylate was hydrolysed with LiOH (2.1 eq.) in MeOH/H2O (1:1) at RT for 48 h. The mixture was concentrated under reduced pressure and extracted with EtOAc. The organic phase was washed with brine, dried (Na2SO4) and concentrated under reduced pressure to give the title compound as white solid. MS (ES) C7H3F3O3S requires: 224, found: 243 (M+H2O+H)+.

1. concentrationThe mixture was concentrated under reduced pressure
2. extractionextracted with EtOAc
3. washThe organic phase was washed with brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated under reduced pressure