Hydrochloric Acid → HCID 12001783, compound

HRID 1715453Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][O:23][C:24]3[C:29]([Cl:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=3[Cl:32])=[CH:16][CH:15]=2)[C@@H:10]([C:33](=[O:51])[N:34]([CH2:38]C2C=C(Cl)C=CC=2CCCOC)[CH:35]2[CH2:37][CH2:36]2)[CH2:9]1)=O)(C)(C)C.Cl.[CH2:53]([Cl:55])Cl>O1CCOCC1>[Cl:55][C:53]1[CH:18]=[CH:19][C:14]([CH2:15][CH2:16][CH2:17][O:20][CH3:21])=[CH:11][C:10]=1[CH2:38][N:34]([CH:35]1[CH2:37][CH2:36]1)[C:33]([C@@H:10]1[C@@H:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][O:23][C:24]3[C:25]([Cl:32])=[CH:26][C:27]([CH3:31])=[CH:28][C:29]=3[Cl:30])=[CH:16][CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9]1)=[O:51]

Participants

Conditions

Temperature: 0 °C

Procedure

Compound D4 (0.076 g, 0.10 mmol) was dissolved in CH2Cl2 (1 mL) and the sol. was cooled to 0° C. 4M HCl in dioxane (1 mL) was added and the reaction mixture was stirred for 1 h at rt. The solvents were evaporated under reduced pressure. Purification of the residue by HPLC yielded the title compound (44 mg, 67%). LC-MS: tR=0.99 min, ES+=661.41.

Workup

customThe solvents were evaporated under reduced pressure
customPurification of the residue by HPLC

Sources & evidence

ORD record: ord-4fc44d890a4d43b3b588de65245b8e2c
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07799805B2

Reaction notes

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