(2S)-1,1,2-Triphenyl-1,2-ethanediol → Esomeprazole

Participants

Reaction Steps

The formation of the inclusion complex can also be carried out from an aqueous solution of omeprazole sodium salt in the presence of a water-miscible solvent and (S)-1,1,2-triphenyl-1,2-ethanediol. Neutralisation with acid results in the formation of a suspension of the same inclusion complex (S)-omeprazole.2[(S)-1,1,2-triphenyl-1,2-ethanediol] which is isolated by filtration.

Provenance & Evidence