Benzylamine → 2-Amino-3-cyano-4-benzalamino-6-dimethylaminoquinoline

HRID 1715812Notes

Reaction equation

HRID 1715812 reaction equation
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]([CH3:17])[CH3:16])[CH:8]=2)[N:3]=1.[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([N:25]=[CH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]([CH3:17])[CH3:16])[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 668503782-Amino-3-cyano-4-chloro-6-dimethylaminoquinoline

Product 1

HCID 675237082-Amino-3-cyano-4-benzalamino-6-dimethylaminoquinoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3 g of 2-amino-3-cyano-4-chloro-6-dimethylaminoquinoline and 6 mL of benzylamine are stirred at 125° C. for 3 hours. The reaction mixture is poured onto 30 mL of water. The precipitated material is filtered off, washed with 20 mL of water. After drying 2.3 g of the title compound is obtained, m.p.: 265° C.

Workup

  1. filtrationThe precipitated material is filtered off
  2. washwashed with 20 mL of water
  3. dry with materialAfter drying 2.3 g of the title compound
  4. customis obtained

Sources & evidence

ORD record
ord-70551868b4ae448e98f95fbb64feef30
Source dataset
uspto-grants-2010_09
Patent number
US07799922B2

Reaction notes

Loading…