(4-Methoxyphenyl)boronic acid → HCID 44455787, compound

HRID 1716309Notes

Reaction equation

HRID 1716309 reaction equation
Cl[CH2:2][S:3]([C:6]1[S:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)(=[O:5])=[O:4].BrC1SC(S(C[N:29]2[CH:34]=[CH:33][CH:32]=[C:31]([OH:35])[C:30]2=[O:36])(=O)=O)=CC=1.COC1C=CC(B(O)O)=CC=1>>[OH:35][C:31]1[C:30](=[O:36])[N:29]([CH2:2][S:3]([C:6]2[S:7][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:9][CH:10]=2)(=[O:5])=[O:4])[CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 3

HCID 201262(4-Methoxyphenyl)boronic acidHCID 59467989HCID 59467989, compoundHCID 68515900HCID 68515900, compound

Product 1

HCID 44455787HCID 44455787, compound

Procedure

The titled compound was synthesized in a similar manner as described in Example 60 by replacing 1-chloromethanesulfonyl-4-methyl-benzene with 2-chloromethanesulfonyl-5-(4-methoxy-phenyl)-thiophene (synthesized from 2-bromo-5-chloromethanesulfonyl-thiophene from Example 63 and 4-methoxy-phenyl boronic acid according the procedure described in example 52 Step A) in Example 60 Step B. MS (EI) 378 (M+H)+.

Sources & evidence

ORD record
ord-c67c46736cab4dc88a599035e252c7fa
Source dataset
uspto-grants-2010_09
Patent number
US07803793B2

Reaction notes

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