Trifluoroacetic acid → HCID 44455706, compound

HRID 1716328Notes

Reaction equation

HRID 1716328 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([CH:18]3[CH2:24][CH2:23][CH2:22][CH2:21][N:20]([O:25]C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[C:19]3=[O:45])(=[O:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:25][N:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH:18]([S:15]([C:12]2[CH:11]=[CH:10][C:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[CH:14][CH:13]=2)(=[O:17])=[O:16])[C:19]1=[O:45]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68515932HCID 68515932, compound

Product 1

HCID 44455706HCID 44455706, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(4′-Methoxy-biphenyl-4-sulfonyl)-1-trityloxy-azepan-2-one prepared from step G (5.1 mg, 0.00826 mmol) in 0.75 ml of anhydrous CH2Cl2 was added 0.75 ml of TFA and the resulting solution was stirred for 30 min. After TLC indicated the completion of the reaction (<30 min), the reaction mixture was concentrated under reduced pressure to gave a crude material, which was then purified by a column chromatography (0˜5% MeOH in CH2Cl2). MS: 376.0 (M+H)+, 398.1 (M+Na)+.

Workup

  1. customthe completion of the reaction (<30 min)
  2. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5733ced10c144a21ab04a1198b429039
Source dataset
uspto-grants-2010_09
Patent number
US07803793B2

Reaction notes

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