Chloroacetone → 1-methoxy-2-methylindolizine

HRID 1716343Notes

Reaction equation

HRID 1716343 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1.Cl[CH2:11][C:12](=O)[CH3:13]>>[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][N:5]2[C:4]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 2532202-(Methoxymethyl)pyridine

Product 1

HCID 113211231-methoxy-2-methylindolizine

Procedure

This compound is obtained starting with 2-(methoxymethyl)pyridine and chloroacetone, using the Tschitschibabin reaction. The product is isolated in the form of a yellow oil which crystallizes in the freezer.

Workup

  1. customThis compound is obtained
  2. customthe Tschitschibabin reaction
  3. customThe product is isolated in the form of a yellow oil which
  4. customcrystallizes in the freezer

Sources & evidence

ORD record
ord-b0390b091ea34b17a5723e6f76c4929f
Source dataset
uspto-grants-2010_09
Patent number
US07803811B2

Reaction notes

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