Water → HCID 12069601, compound

HRID 1716356Notes

Reaction equation

HRID 1716356 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:14][O:15][C:16]1[C:17]([CH3:25])=[CH:18][N:19]2[C:24]=1[CH:23]=[CH:22][CH:21]=[CH:20]2.O.ClCCl>ClCCCl>[CH3:14][O:15][C:16]1[C:17]([CH3:25])=[C:18]([S:10]([C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)(=[O:12])=[O:11])[N:19]2[C:24]=1[CH:23]=[CH:22][CH:21]=[CH:20]2

Participants

6

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 74044-Nitrobenzenesulfonyl chlorideHCID 113211231-methoxy-2-methylindolizine

Product 1

HCID 12069601HCID 12069601, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent2×

Procedure

690 mg (3.1 mmol) of 4-nitrobenzenesulphonyl chloride in solution in 4 ml of 1,2-dichloroethane are added to 500 mg (3.1 mmol) of 1-methoxy-2-methylindolizine dissolved in 8 ml of 1,2-dichloroethane, and the medium is stirred at room temperature for 20 hours. The reaction medium is poured over water and dichloromethane. The organic phase is separated after settling out, washed with water, dried over sodium sulphate and concentrated under reduced pressure.

Workup

  1. customThe organic phase is separated
  2. washwashed with water
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-114233586ad6424598f0cb3b7d325fb5
Source dataset
uspto-grants-2010_09
Patent number
US07803811B2

Reaction notes

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