1-Methylpiperazine → HCID 16059211, compound

HRID 1716415Notes

Reaction equation

HRID 1716415 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[N:27]=[C:26]3Cl)[CH2:21][CH2:20]2)=[O:18])=[C:9]1[CH3:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:36][N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[N:27]=[C:26]3[N:40]3[CH2:41][CH2:42][N:37]([CH3:36])[CH2:38][CH2:39]3)[CH2:21][CH2:20]2)=[O:18])=[C:9]1[CH3:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 16059210HCID 16059210, compound

Product 1

HCID 16059211HCID 16059211, compoundYield 22%

Conditions

Temperature
90 °C

Procedure

A mixture of 20 mg (0.041 mmol) of (1-benzyl-2-methyl-1H-indol-3-yl)-[4-(2-chloro-benzoimidazol-1-yl)-piperidin-1-yl]-methanone (the preparation of which is described in example 1) and N-methyl-piperazine was heated in a sealed tube at 90° C. for 8 hours, cooled to RT and then concentrated in vacuo. Flash chromatography (CH2Cl2/MeOH 9/1) afforded 5 mg (22%) of (1-benzyl-2-methyl-1H-indol-3-yl)-{4-[2-(4-methyl-piperazin-1-yl)-benzoimidazol-1-yl]-piperidin-1-yl}-methanone as white solid. ES-MS m/e (%): 547.5 (M+H+).

Workup

  1. customthe preparation of which
  2. temperaturecooled to RT
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ec0bc9abad99435587628696caab5aa1
Source dataset
uspto-grants-2010_09
Patent number
US07803815B2

Reaction notes

Loading…