Methanol → Methyl 6-chloro-1H-indole-3-carboxylate

HRID 1716420Notes

Reaction equation

HRID 1716420 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([OH:13])=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:14]O>OS(O)(=O)=O>[CH3:14][O:12][C:11]([C:6]1[C:5]2[C:9](=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=2)[NH:8][CH:7]=1)=[O:13]

Participants

4

Reactant 2

HCID 887MethanolHCID 184532356-chloro-1H-indole-3-carboxylic acid

Product 1

HCID 49108265Methyl 6-chloro-1H-indole-3-carboxylate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

1 g of 6-chloro-1H-indole-3-carboxylic acid were heated at reflux in MeOH with 3 drop of concentrated H2SO4 overnight. Concentration in vacuo afforded the title compound in quantitative yield.

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-42a61e3d939f4304bc7bb329142fb84e
Source dataset
uspto-grants-2010_09
Patent number
US07803815B2

Reaction notes

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