反应详情

A solution of piperidin-4-ylacetic acid tert-butyl ester (10.72 g, 50.0 mmol) in chloroform (100 ml) was added to a solution of 9-fluorenylmethoxycarbonyl isothiocyanate (14.07 g, 50.0 mmol) in chloroform (100 ml) and the mixture was stirred at room temperature for 1 hour. Then, piperidine (80 ml) was added and the mixture was stirred at room temperature for 30 minutes. After the reaction solution was concentrated, water was added, and it was extracted with ethyl acetate and washed with a saturated brine. The organic layer was dried over magnesium sulfate and the residue obtained by vacuum concentration was washed with isopropyl ether and the title compound was obtained (11.35 g, 98%).

1. stirringthe mixture was stirred at room temperature for 30 minutes
2. concentrationAfter the reaction solution was concentrated
3. additionwater was added
4. extractionit was extracted with ethyl acetate
5. washwashed with a saturated brine
6. dry with materialThe organic layer was dried over magnesium sulfate
7. customthe residue obtained by vacuum concentration
8. washwas washed with isopropyl ether