反应详情

温度

130 °C

A suspension of (6-bromopyridin-2-yl)-(4-methylpyridin-2-yl)amine (1.00 g, 3.79 mmol), 5-acetylthiophene-2-boronic acid (644 mg, 3.79 mmol), tetrakis triphenylphosphine palladium (440 mg, 0.38 mmol), sodium hydrogen carbonate (480 mg, 5.68 mmol) in dimethoxyethane-water (12 ml) was heated and stirred in an Ar stream at 130° C. for 12 hours. Water was added to the reaction solution and extracted with ethyl acetate. After the organic layer was washed with a saturated brine and dried over anhydrous magnesium sulfate, the residue obtained by concentration in vacuo was washed with tetrahydrofuran-ethyl acetate (1:1), dried, and the title compound (426 mg, 36%) was obtained.

1. temperaturewas heated
2. extractionextracted with ethyl acetate
3. washAfter the organic layer was washed with a saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe residue obtained by concentration in vacuo
6. washwas washed with tetrahydrofuran-ethyl acetate (1:1)
7. customdried