1,4-Dioxane hydrochloride → HCID 68512392, compound

HRID 1716566Notes

Reaction equation

HRID 1716566 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][C:21]([CH3:23])=[CH:22][C:17]=3[N:16]=[C:15]2[CH:24]2[CH2:26][CH2:25]2)[CH:10]([O:27][CH3:28])[CH2:9]1)=O)(C)(C)C.[ClH:29].O1CCOCC1>>[ClH:29].[CH:24]1([C:15]2[N:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]3[O:27][CH3:28])[C:18]3[CH:19]=[CH:20][C:21]([CH3:23])=[CH:22][C:17]=3[N:16]=2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68513326HCID 68513326, compound

Product 1

HCID 68512392HCID 68512392, compound

Procedure

A solution of 4-(2-cyclopropyl-5-methyl-benzoimidazol-1-yl)-3-methoxy-piperidine-1-carboxylic acid tert-butyl ester (650 mg, 1.69 mmol) in a 4 M HCl/dioxane (3 mL) solution was stirred for 0.5 h. The solvent was removed to provide 2-cyclopropyl-1-(3-methoxy-piperidin-4-yl)-5-methyl-1H-benzoimidazole hydrochloride salt in quantitative yield without further purification.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-76fbb124e5024dbebacf5ffa01b5abcf
Source dataset
uspto-grants-2010_09
Patent number
US07803816B2

Reaction notes

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