Hydrochloric Acid → HCID 68509884, compound

HRID 1716570Notes

Reaction equation

HRID 1716570 reaction equation
[CH3:1][C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C@H:8]2[CH2:20][OH:21])[C:5]2[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:4]=2[N:3]=1.[ClH:27]>O1CCOCC1>[ClH:27].[ClH:27].[CH3:1][C:2]1[N:6]([C@@H:7]2[CH2:12][CH2:11][NH:10][CH2:9][C@H:8]2[CH2:20][OH:21])[C:5]2[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68509007HCID 68509007, compound

Product 1

HCID 68509884HCID 68509884, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Racemic trans-4-(2,5-Dimethylbenzimidazol-1-yl)-3-hydroxymethyl-N-Boc piperidine (250 mg; 0.70 mmol) was dissolved in 4M HCl in dioxane for 60 min. All volatiles were then removed under reduced pressure and the resulting sticky solid was triturated with diethyl ether to yield racemic trans-4-(2,5-dimethylbenzimidazol-1-yl)-3-hydroxymethylpiperidine dihydrochloride as a white solid (231 mg; quant.).

Workup

  1. customAll volatiles were then removed under reduced pressure
  2. customthe resulting sticky solid was triturated with diethyl ether

Sources & evidence

ORD record
ord-c49351f32c114711962e694f1c403be9
Source dataset
uspto-grants-2010_09
Patent number
US07803816B2

Reaction notes

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