HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68507641, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68510105 | HCID 68510105 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68507641 | HCID 68507641 | — |
Reaction Steps
Racemic trans-3-[2-hydroxy-2-methylpropoxy]-4-[2,5-dimethylbenzimidazol-1yl]-N-Boc-piperidine (320 mg; 0.77 mmol) was treated with 4M HCl in dioxane for 1 h after which all volatiles were removed under reduced pressure to yield the product trans-3-[2-hydroxy-2-methylpropoxy]-4-[2,5-dimethylbenzimidazol-1yl]-piperidine dihydrochloride (300 mg; quant.). LRMS (M+1)—Calculated: 317.2. Found: 317.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803816B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-73eeb59e71284177ac66d610ba2cf16e |
| Source note | uspto-grants-2010_09 |