Hydrochloric Acid → HCID 68507641, compound

HRID 1716573Notes

Reaction equation

HRID 1716573 reaction equation
[OH:1][C:2]([CH3:30])([CH3:29])[CH2:3][O:4][C@H:5]1[C@H:10]([N:11]2[C:15]3[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:14]=3[N:13]=[C:12]2[CH3:21])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:31]>O1CCOCC1>[ClH:31].[ClH:31].[OH:1][C:2]([CH3:30])([CH3:29])[CH2:3][O:4][C@H:5]1[C@H:10]([N:11]2[C:15]3[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:14]=3[N:13]=[C:12]2[CH3:21])[CH2:9][CH2:8][NH:7][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68510105HCID 68510105, compound

Product 1

HCID 68507641HCID 68507641, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Racemic trans-3-[2-hydroxy-2-methylpropoxy]-4-[2,5-dimethylbenzimidazol-1yl]-N-Boc-piperidine (320 mg; 0.77 mmol) was treated with 4M HCl in dioxane for 1 h after which all volatiles were removed under reduced pressure to yield the product trans-3-[2-hydroxy-2-methylpropoxy]-4-[2,5-dimethylbenzimidazol-1yl]-piperidine dihydrochloride (300 mg; quant.). LRMS (M+1)—Calculated: 317.2. Found: 317.2.

Workup

  1. customwere removed under reduced pressure

Sources & evidence

ORD record
ord-73eeb59e71284177ac66d610ba2cf16e
Source dataset
uspto-grants-2010_09
Patent number
US07803816B2

Reaction notes

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