HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68513399, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68510861 | HCID 68510861 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68513399 | HCID 68513399 | — |
Reaction Steps
4-(5-fluoro-2-methylbenzimidazol-1-yl)-3-methoxy-Boc-piperidine (185 mg, 0.23 mmol) was dissolved in 4M HCl in dioxane and stirred for 90 minutes after which all volatiles were removed under reduced pressure. The resulting gummy solid was triturated with diethyl ether to yield 4-(5-fluoro-2-methylbenzimidazol-1-yl)-3-methoxy-piperidine dihydrochloride as an off-white solid (76 mg, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803816B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-1c13c5f95397401cb84a522be828fb73 |
| Source note | uspto-grants-2010_09 |