Hydrochloric Acid → HCID 68513399, compound

HRID 1716575Notes

Reaction equation

HRID 1716575 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][C:5]2[N:6]([CH:10]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH:11]3[O:23][CH3:24])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1.[ClH:27]>O1CCOCC1>[ClH:27].[ClH:27].[F:1][C:2]1[CH:26]=[CH:25][C:5]2[N:6]([CH:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH:11]3[O:23][CH3:24])[C:7]([CH3:9])=[N:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68510861HCID 68510861, compound

Product 1

HCID 68513399HCID 68513399, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-(5-fluoro-2-methylbenzimidazol-1-yl)-3-methoxy-Boc-piperidine (185 mg, 0.23 mmol) was dissolved in 4M HCl in dioxane and stirred for 90 minutes after which all volatiles were removed under reduced pressure. The resulting gummy solid was triturated with diethyl ether to yield 4-(5-fluoro-2-methylbenzimidazol-1-yl)-3-methoxy-piperidine dihydrochloride as an off-white solid (76 mg, quant.).

Workup

  1. customwere removed under reduced pressure
  2. customThe resulting gummy solid was triturated with diethyl ether

Sources & evidence

ORD record
ord-1c13c5f95397401cb84a522be828fb73
Source dataset
uspto-grants-2010_09
Patent number
US07803816B2

Reaction notes

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