3-(3-Cyano-1H-Indol-5-yl)-3-phenyl-propionic acid ethyl ester → 5-(3-Hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile

HRID 1716671Notes

Reaction equation

HRID 1716671 reaction equation
C([O:3][C:4](=O)[CH2:5][CH:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][CH:17]=[C:16]2[C:22]#[N:23])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.OCCC(C1C=CC=C2C=1C(C#N)=CN2)C1C=CC=CC=1>>[OH:3][CH2:4][CH2:5][CH:6]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][CH:17]=[C:16]2[C:22]#[N:23])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 673558733-(3-Cyano-1H-Indol-5-yl)-3-phenyl-propionic acid ethyl esterHCID 673762644-(3-hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile

Product 1

HCID 673767595-(3-Hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile

Procedure

5-(3-Hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile LXV (1.24 g, 79%) was prepared from 3-(3-cyano-1H-Indol-5-yl)-3-phenyl-propionic acid ethyl ester using the procedure described for 4-(3-hydroxy-1-phenyl-propyl)-1H-indole-3-carbonitrile LX (see Example 14).

Sources & evidence

ORD record
ord-1d7e4738977c4704b46fae4f55acb668
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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