3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(7-Fluoro-1H-indol-5-yl)-N-Methyl-3-phenyl-acrylamide

HRID 1716685Notes

Reaction equation

HRID 1716685 reaction equation
C([O:3][C:4](=O)[CH:5]=[C:6]([C:13]1[CH:14]=[C:15]2[C:19](=[C:20]([F:22])[CH:21]=1)[NH:18][CH:17]=[CH:16]2)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:39][NH:40]2)C1C=CC=CC=1)C>>[F:22][C:20]1[CH:21]=[C:13]([C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:5][C:4]([NH:40][CH3:39])=[O:3])[CH:14]=[C:15]2[C:19]=1[NH:18][CH:17]=[CH:16]2

Participants

3

Reactant 2

HCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 673556553-(7-fluoro-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673553863-(7-Fluoro-1H-indol-5-yl)-N-Methyl-3-phenyl-acrylamideYield 59%

Procedure

3-(7-Fluoro-1H-indol-5-yl)-N-Methyl-3-phenyl-acrylamide LXXXII (120 mg, 59% yield) was prepared from 3-(7-fluoro-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described above for 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Sources & evidence

ORD record
ord-3be41788739d42cd8d9ee7c37ae90435
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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