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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716685Generated: October 25, 2026

3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(7-Fluoro-1H-indol-5-yl)-N-Methyl-3-phenyl-acrylamide

https://huagongshe.com/reaction/1716685

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Reactant3-(7-fluoro-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355655—
Product3-(7-Fluoro-1H-indol-5-yl)-N-Methyl-3-phenyl-acrylamideHCID 6735538659%

Reaction Steps

3-(7-Fluoro-1H-indol-5-yl)-N-Methyl-3-phenyl-acrylamide LXXXII (120 mg, 59% yield) was prepared from 3-(7-fluoro-1H-indol-5-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described above for 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803830B2
Source datasetuspto-grants-2010_09
ORD IDord-3be41788739d42cd8d9ee7c37ae90435
Source noteuspto-grants-2010_09