3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl ester

HRID 1716696Notes

Reaction equation

HRID 1716696 reaction equation
Br[C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]2[C:3]=1[C:4]([C:13]#[N:14])=[CH:5][NH:6]2.[CH2:15]([O:17][C:18](=[O:38])[CH:19]=[C:20](C1C=CC=C2C=1C(C#N)=CN2)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:16]>>[CH2:15]([O:17][C:18](=[O:38])[CH:19]=[C:20]([C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]2[C:3]=1[C:4]([C:13]#[N:14])=[CH:5][NH:6]2)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:16]

Participants

3

Reactant 2

HCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 673557774-bromo-6-methoxy-1H-indole-3-carbonitrile

Product 1

HCID 673559173-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl esterYield 54%

Procedure

3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl ester CXXIX (0.81 g, 54% yield) was prepared from 4-bromo-6-methoxy-1H-indole-3-carbonitrile using the procedure described above for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Sources & evidence

ORD record
ord-231c2d1377c444b592f6d393cc19e5e4
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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