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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716696Generated: October 25, 2026

3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl ester

https://huagongshe.com/reaction/1716696

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Reactant4-bromo-6-methoxy-1H-indole-3-carbonitrileHCID 67355777—
Product3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 6735591754%

Reaction Steps

3-(3-Cyano-6-methoxy-1H-indol-4-yl)-3-phenyl-acrylic acid ethyl ester CXXIX (0.81 g, 54% yield) was prepared from 4-bromo-6-methoxy-1H-indole-3-carbonitrile using the procedure described above for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803830B2
Source datasetuspto-grants-2010_09
ORD IDord-231c2d1377c444b592f6d393cc19e5e4
Source noteuspto-grants-2010_09