6-Bromo-1H-indole-3-carbonitrile → 3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

HRID 1716711Notes

Reaction equation

HRID 1716711 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18](C1C=C(OC)C=C2C=1C=CN2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18]([C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:14]

Participants

3

Reactant 2

HCID 114700676-Bromo-1H-indole-3-carbonitrileHCID 673560903-(6-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673557733-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

Procedure

3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CLII was prepared from 6-bromo-1H-indole-3-carbonitrile using the procedure described above for preparation of 3-(6-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester CXVI (Example 25).

Sources & evidence

ORD record
ord-c6977e306abd47c988b35b42f07bfc3f
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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