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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1716711Generated: November 1, 2026

6-Bromo-1H-indole-3-carbonitrile → 3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

https://huagongshe.com/reaction/1716711

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromo-1H-indole-3-carbonitrileHCID 11470067—
Reactant3-(6-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67356090—
Product3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355773—

Reaction Steps

3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CLII was prepared from 6-bromo-1H-indole-3-carbonitrile using the procedure described above for preparation of 3-(6-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester CXVI (Example 25).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803830B2
Source datasetuspto-grants-2010_09
ORD IDord-c6977e306abd47c988b35b42f07bfc3f
Source noteuspto-grants-2010_09