3-Pyridineacrylic acid ethyl ester → 3-(1H-Indol-6-yl)-3-pyridin-3-yl-acrylic acid ethyl ester

HRID 1716714Notes

Reaction equation

HRID 1716714 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH2:11]([O:13][C:14](=[O:23])[CH:15]=[CH:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH3:12]>>[CH2:11]([O:13][C:14](=[O:23])[CH:15]=[C:16]([C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1)[C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[CH3:12]

Participants

3

Reactant 2

HCID 5833373-Pyridineacrylic acid ethyl esterHCID 6764936-Bromoindole

Product 1

HCID 673559243-(1H-Indol-6-yl)-3-pyridin-3-yl-acrylic acid ethyl ester

Procedure

3-(1H-Indol-6-yl)-3-pyridin-3-yl-acrylic acid ethyl ester CLVII was prepared from 6-bromo-1H-indole and 3-pyridin-3-yl-acrylic acid ethyl ester using the procedure described above for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterLVIII (Example 14).

Sources & evidence

ORD record
ord-c2a717681ed147959a252557ff18cc94
Source dataset
uspto-grants-2010_09
Patent number
US07803830B2

Reaction notes

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