反应详情

A mixture of methanesulfonic acid 2-(2-cyano-1H-indol-5-yl)-2-phenyl-ethyl ester CCLXXI (0.24 g) and a solution of methylamine (33% in EtOH, 15 mL) was heated at reflux for 2 hours. The resulting mixture was evaporated under reduced pressure and the residue was purified by flash chromatography (DCM/(DCM+MeOH+NH4OH 60/10/1), 70/30 to 50/50) to give 80 mg of 5-(2-methylamino-1-phenyl-ethyl)-1H-indole-2-carbonitrile CCLXXII as a light yellow foam. MS=290 [M+H]+.

1. temperatureat reflux for 2 hours
2. customThe resulting mixture was evaporated under reduced pressure
3. customthe residue was purified by flash chromatography (DCM/(DCM+MeOH+NH4OH 60/10/1), 70/30 to 50/50)