Methyl 4-(1H-benzo[d]imidazol-2-yl)benzoate → HCID 57550190, compound

HRID 1716840Notes

Reaction equation

HRID 1716840 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=O)=[CH:12][CH:11]=1.[CH3:20][O:21][C:22](=[O:27])[C@H:23](CO)[NH2:24]>>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:19]=[CH:18][C:13]([C:14]2[O:16][CH:17]=[C:23]([C:22]([O:21][CH3:20])=[O:27])[N:24]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 2328806Methyl 4-(1H-benzo[d]imidazol-2-yl)benzoateHCID 2723731(S)-methyl 2-amino-3-hydroxypropanoate

Product 1

HCID 57550190HCID 57550190, compound

Procedure

Using essentially the same procedures described in Examples 23 and 24 and employing methyl 4-(1-H-benzimidazol-2-yl)benzoate and serine methyl ester as starting materials the title compound was obtained and identified by NMR and mass spectral analyses. 1HNMR (400 MHz, DMSO-d6): 3.86 (s, 3H), 7.22-7.24 (m, 2H), 7.62 (d, J=3.2 Hz, 2H), 8.19 (d, J=7.6 Hz, 2H), 8.36 (d, J=8 Hz, 2H), 9.02 (s, 1H), 13.1 (s, 1H). LCMS (ESI+) 319 (MH+).

Sources & evidence

ORD record
ord-9af8a364a6d54e85a5b7735bdaa16204
Source dataset
uspto-grants-2010_09
Patent number
US07803825B2

Reaction notes

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