反应详情

A stirred solution of ethyl bromopyruvate (50.2 g, 257.2 mmol) in EtOH was treated with urea (23.2 g, 385.8 mmol) refluxed overnight and concentrated under reduced pressure. The resultant residue was dissolved in EtOAC and water. The layers were separated and the aqueous layer washed with EtOAC. The combined organic layers were washed successively with saturated sodium chloride, dried over Mg2SO4 and concentrated under reduced pressure to give the title product in 85% yield, identified by NMR and mass spectral analyses. LCMS (ESI+) 157.1 (MH+).

1. temperaturerefluxed overnight
2. concentrationconcentrated under reduced pressure
3. dissolutionThe resultant residue was dissolved in EtOAC and water
4. customThe layers were separated
5. washthe aqueous layer washed with EtOAC
6. washThe combined organic layers were washed successively with saturated sodium chloride
7. dry with materialdried over Mg2SO4
8. concentrationconcentrated under reduced pressure