Phenylboronic Acid → HCID 59654853, compound

HRID 1717040Notes

Reaction equation

HRID 1717040 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[N:16]=[C:17](Cl)[S:18][CH:19]=2)=[O:14])[CH:7]=1)[CH3:2].[C:22]1(B(O)O)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[N:16]=[C:17]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[S:18][CH:19]=2)=[O:14])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 59654790HCID 59654790, compound

Product 1

HCID 59654853HCID 59654853, compound

Procedure

{3-[(2-Chloro-thiazole-4-carbonyl)-amino]-phenyl}-acetic acid ethyl ester (114 mg, 0.35 mmol) was coupled to phenylboronic acid using Method E, except that the reaction mixture was heated for 140 min. The crude residue was purified by column chromatography using 33% EtOAc in heptane to give the title compound.

Workup

  1. temperaturewas heated for 140 min
  2. customThe crude residue was purified by column chromatography

Sources & evidence

ORD record
ord-cf7a2ff7137f4cc2a733ead06defd483
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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