HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3-Chlorophenyl)furan-2-carboxylic acid → 5-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3-Chlorophenyl)furan-2-carboxylic acid | HCID 736256 | — |
| Reactant | Ethyl 5-amino-1H-indole-2-carboxylate | HCID 10726872 | — |
| Product | 5-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-1H-indole-2-carboxylic acid ethyl ester | HCID 59654633 | — |
Reaction Steps
5-(3-Chloro-phenyl)-furan-2-carboxylic acid (65) (54 mg, 0.24 mmol) was coupled to ethyl ester (58) (50 mg, 0.24 mmol) using Method C. The crude residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803841B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-db417808bbee4a0bb5f7a0bfb632ec27 |
| Source note | uspto-grants-2010_09 |