5-(3,5-Dichlorophenyl)furan-2-carboxylic acid → 5-(3,5-Dichloro-phenyl)-furan-2-carboxylic acid (3-cyanomethyl-phenyl)-amide

HRID 1717068Notes

Reaction equation

HRID 1717068 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:13][C:12]([C:14]([OH:16])=O)=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH2:17][C:18]1[CH:19]=[C:20]([CH2:24][C:25]#[N:26])[CH:21]=[CH:22][CH:23]=1>>[C:25]([CH2:24][C:20]1[CH:19]=[C:18]([NH:17][C:14]([C:12]2[O:13][C:9]([C:4]3[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=3)=[CH:10][CH:11]=2)=[O:16])[CH:23]=[CH:22][CH:21]=1)#[N:26]

Participants

3

Reactant 2

HCID 40663695-(3,5-Dichlorophenyl)furan-2-carboxylic acidHCID 4847850(3-Amino-phenyl)-acetonitrile

Product 1

HCID 596547205-(3,5-Dichloro-phenyl)-furan-2-carboxylic acid (3-cyanomethyl-phenyl)-amide

Procedure

Carboxylic acid (67) (62 mg, 0.24 mmol) was coupled to aniline (80) (32 mg, 0.24 mmol) using Method C. After work-up, the solid was recrystallised from MeCN (3 ml) to give the title compound.

Workup

  1. customAfter work-up, the solid was recrystallised from MeCN (3 ml)

Sources & evidence

ORD record
ord-0edc002a353245bdaa66fd3036b99c57
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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