Bromobenzene → 2-Phenylfuran

HRID 1717111Notes

Reaction equation

HRID 1717111 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:8]1[CH:12]=[CH:11][CH:10]=[C:9]1B(O)O>>[C:2]1([C:9]2[O:8][CH:12]=[CH:11][CH:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7961BromobenzeneHCID 2734357Furan-2-boronic acid

Product 1

HCID 5193632-Phenylfuran

Procedure

Bromobenzene (1.5 g, 9.55 mmol) was coupled to 2-furylboronic acid (1.75 g, 15.6 mmol) using Method E. The crude compound was purified by column chromatography using a stepped gradient of 5-10% EtOAc in heptane to give the title compound.

Workup

  1. customThe crude compound was purified by column chromatography

Sources & evidence

ORD record
ord-49d3c8e603b34e659589a424576c072d
Source dataset
uspto-grants-2010_09
Patent number
US07803841B2

Reaction notes

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