化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl 2-(3-aminophenoxy)acetate → [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 2-(3-aminophenoxy)acetate | HCID 412308 | — |
| 反応物 | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| 生成物 | [3-(5-Bromo-2-fluoro-benzoylamino)-phenoxy]-acetic acid ethyl ester | HCID 40356283 | — |
反応手順
5-Bromo-2-fluoro-benzoic acid (250 mg, 1.14 mmol) was coupled to aniline (64) (245 mg, 1.25 mmol) using Method D. The residue was purified by column chromatography eluting with a stepped gradient of 10-15% EtOAc in heptane to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07803841B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-249a52a65e70453fa851bc1a3611b54c |
| 出典メモ | uspto-grants-2010_09 |