Ethyl 3-(3-Aminophenyl)propionate → 3-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]amino}-phenyl)-propionic acid ethyl ester

HRID 1717150Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1717150
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20](=[O:30])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH2:29])[CH:24]=1)[CH3:18]>>[CH2:17]([O:19][C:20](=[O:30])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:16])[CH:24]=1)[CH3:18]

Komponenten

3

Edukt 2

HCID 82314Ethyl 3-(3-Aminophenyl)propionateHCID 210817086-(4-Fluorophenyl)picolinic acid

Produkt 1

HCID 596547583-(3-{[6-(4-Fluoro-phenyl)-pyridine-2-carbonyl]amino}-phenyl)-propionic acid ethyl ester

Versuchsvorschrift

Carboxylic acid (152) (50 mg, 0.23 mmol) was coupled to aniline (124) (45 mg, 0.23 mmol) using Method C. The residue was purified by column chromatography eluting with 30% EtOAc in heptane to give the title compound.

Aufarbeitung

  1. customThe residue was purified by column chromatography
  2. washeluting with 30% EtOAc in heptane

Quellen und Nachweise

ORD-Eintrag
ord-6645fed6bf7d44adbe4590ee9b2fd6ec
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07803841B2

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