反应详情

To a solution of 5-[(benzyloxy)methyl]-N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (4.29 g) obtained in Example 94 in DMF (60 ml)-methanol (180 ml) was added palladium-carbon (1.0 g). The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 5 days, and the insoluble material was filtered off. The solvent was evaporated, and the residue was purified by silica gel column (hexane/ethyl acetate=1/1 to ethyl acetate/methanol=4/1). The resultant product was recrystallized from ethyl acetate/hexane to give the title compound as a colorless powder (2.56 g, 76%).

1. filtrationthe insoluble material was filtered off
2. customThe solvent was evaporated
3. customthe residue was purified by silica gel column (hexane/ethyl acetate=1/1 to ethyl acetate/methanol=4/1)
4. customThe resultant product was recrystallized from ethyl acetate/hexane