Hydrogen chloride-ethyl acetate → HCID 68518162, compound

HRID 1717349Notes

Reaction equation

HRID 1717349 reaction equation
[F:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH2:21][C:22]([F:25])([F:24])[F:23])=[O:19])=[CH:14][CH:13]=2)[N:10]=[N:9][C:8]=1[C:26]([NH:28][CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C)=[O:27].[ClH:39].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:39].[NH2:31][CH2:30][CH2:29][NH:28][C:26]([C:8]1[N:9]=[N:10][N:11]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([NH:20][CH2:21][C:22]([F:24])([F:25])[F:23])=[O:19])=[CH:16][CH:17]=2)[C:7]=1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][F:1])=[O:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86629809HCID 86629809, compound

Product 1

HCID 68518162HCID 68518162, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl [2-({[5-(5-fluoropentyl)-1-(4-{[(2,2,2-trifluoroethyl)amino]carbonyl}phenyl)-1H-1,2,3-triazol-4-yl]carbonyl}amino)ethyl]carbamate (0.86 g) obtained in Example 219 in ethyl acetate (10 ml) was added 4N hydrochloric acid/ethyl acetate solution (10 ml), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, diisopropyl ether was added to the obtained residue, and the resultant precipitate was collected by filtration to give the title compound as a white powder (0.76 g, 99%).

Workup

  1. customThe solvent was evaporated under reduced pressure, diisopropyl ether
  2. additionwas added to the obtained residue
  3. filtrationthe resultant precipitate was collected by filtration

Sources & evidence

ORD record
ord-0dc8cf8bcce047a7badeefa4a68610c5
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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